Publications

Cornell Publications:

"PET Imaging of Soluble Yttrium-86-Labeled Carbon Nanotubes in Mice" McDevitt M. R., Chattopadhyay D., Jaggi J. S., Finn, R. D., Zanzonico, P. B., Villa, C., Rey, D., Mendenhall, J., Batt, C. A., Njardarson, J. T., Scheinberg, D. A. PLoS ONE 2007, 2, e907.

“Tumor Targeting with Antibody-Functionalized, Radiolabeled Carbon Nanotubes" Michael R. McDevitt, Debjit Chattopadhyay, Barry J. Kappel, Jaspreet Singh Jaggi, Scott R. Schiffman, Christophe Antczak, Jon T. Njardarson, Renier Brentjens, and David A. Scheinberg J. Nucl. Med. 2007, 48, 1180-1189.

“Highly Selective Copper-Catalyzed Ring Expansion of Vinyl Thiiranes:  Application to Synthesis of Biotin and the Heterocyclic Core of Plavix®” Rogers, E.; Araki, H.; Batory, L. A.; McInnis, C. E.; Njardarson, J. T.   J. Am. Chem. Soc. 2007, 129,2768.

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“Copper Catalyzed Rearrangement of Vinyl Oxiranes”, Batory, L. A.; McInnis, C. E.; Njardarson, J. T. J. Am. Chem. Soc. 2006, 128, 16054.

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Undergraduate, Graduate and Postdoctoral Publications:

“Synthetic Analogues of Migrastatin That Inhibit Mammary Tumor Metastasis in Mice” Shan, D.; Chen, L.; Njardarson, J. T.; Gaul, C.; Ma, X.; Danishefsky, S. J.; Huang, X.-Y. Proc. Natl. Acad. Sc.i U. S. A. 2005, 102, 3772.

“The Migrastatin Family:  Discovery of Promising Tumor Cell Migration Inhibitors by Chemical Synthesis” Gaul, C.; Njardarson, J. T.; Shan, D.; Dorn, D. C.; Wu, K.-D.; Tong, W. P.; Huang, X.-Y.; Moore, M. A.; Danishefsky, S. J.  J. Am. Chem. Soc. 2004, 126, 11326.

“Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure-Activity Studies of (+)-Migrastatin” Njardarson, J. T.’ Gaul, C.; Shan, D.; Huang, X.-Y.; Danishefsky, S. J. J. Am. Chem. Soc. 2004, 126, 1038.

”Application of Phenolic Oxidation Chemistry in Synthesis: Preparation of the BCE Ring System of Ryanodine” Wood, J. L.; Graeber, J. K.; Njardarson, J. T. Tetrahedron 2003, 59, 8855.

“Innovation and Art in Organic Chemistry:  Synthetic Efforts Toward the Phomoidrides” Spiegel, D. A.; Njardarson, J. T.; McDonald, I.; Wood, J. L. Chem. Rev. 2003, 103, 2691.

“The Total Synthesis of (+)-Migrastatin” Gaul, C.; Njardarson, J. T.; Danishefsky, S. J. J. Am. Chem. Soc. 2003, 125, 6042.
 
“Application of Hitherto Unexplored Macrocyclization Strategies in the Epothilone Series:  Novel Epothilone Analogs by Total Synthesis” Njardarson, J. T.; Biswas, K.; Danishefsky, S. J. Chem Commun. 2002, 2759.

“Total Syntheses of [17]- and [18]Dehydrodesoxyepothilones B via a Concise Ring-Closing Metathesis-Based Strategy:  Correlation of Ring Size with Biological Activity in the Epothilones Series” Rivkin, A.; Njardarson, J. T.; Biswas, K.; Chou, T-C.; Danishefsky, S. J. J. Org. Chem. 2002, 67, 7737.

“Highly Concise Routes to Epothilones:  The Total Synthesis and Evaluation of Epothilone 490” Biswas, K.; Lin, H.; Njardarson, J. T.; Chappell, M. D.; Chou, T.-C.; Guan, Y.; Tong, W. P.; He, L.; Horwitz, S. B.; Danishefsky, S. J. J. Am. Chem. Soc. 2002, 124, 9825.

“CP-263,114 Synthetic Studies.  Construction of an Isotwistane Ring System via Rhodium Carbenoid C-H Insertion” Spiegel, D. A.; Njardarson, J. T.; Wood, J. L. Tetrahedron 2002, 58, 6545.

“Reactive Dienes:  Intramolecular Aromatic Oxidation of 3-(2-Hydroxyphenyl)-propionic Acids” Drutu, I.; Njardarson, J. T.; Wood, J. L. Org. Lett. 2002, 4, 493.

“An Expeditious Approach Towards the Total Synthesis of CP-263,114”, Njardarson, J. T.; MacDonald, I.; Spiegel, D. A.; Inoue, M.; Wood, J. L. Org. Lett. 2001, 3, 2435.

“Evolution of a Synthetic Approach to CP-263,114”, Njardarson, J. T.; Wood, J. L. Org. Lett. 2001, 3, 2431.

“Concise Synthetic Route to Pure Isomers of the Antifungal Agents (E)- and (Z)-1,2-Diaryl-3-(1-imidazolyl)-1-propenes”, Geirsson, J. K. F.; Gudmundsson, B. O.; Johannesdottir, J. F.; Njardarson, J. T.; Skulason, V. Acta Chem. Scand. 1995, 49, 423.

“A Facile Synthesis of a-Phosphono Esters through Methoxycarbonylation of a-Phosphono Carbanions”, Geirsson, J. K. F.; Njardarson, J. T. Tetrahedron Lett 1994, 35, 9071.

Book Chapters:
“Radicicol and the Epothilones:  Total Synthesis of Novel Anti Cancer Agents Using Ring Closing Metathesis” Njardarson, J. T.; Garbaccio, R. M.; Danishefsky, S. J., in “Handbook of Metathesis”, Ed. Grubbs, Robert H.; Wiley, New York, 2003, Chapter 2.9, Appendix 3, p353.

Patents:
"Production of 2,5-Dihydrofurans and Analogous Compounds" Njardarson, J.; Batory, L.; Bricachek, M. Bauer, R. A.; Rogers, E. PCT Int. Appl.,  (2007), WO  2007108999

"Single Wall Carbon Nanotube Constructs For Targeting Tumors" Scheinberg, D.; McDewitt, M.; Antczak, C.; Chattopahyay, D.; May, R.; Njardarson, J.; Phillips M. R.; PCT Int. Appl., (2007), WO 2007016466.

"Preparation of Migrastatin and its Analogs for use in Pharmaceutical Compositions for the Treatment of Cancer" Danishefsky, S. J.; Gaul, C.; Njardarson, J. T., Moore, M. A. S.; Wu, K.; Dorn, D. C.; Mandal, M.; PCT Int. Appl., (2006), WO 2006001967.
 
 "Preparation of Migrastatin Analogs and their Biological Activity" Huang, X.-Y.; Danishefsky, S. J.; Gaul, C.; Njardarson, J. T.; PCT Int. Appl. (2004), WO 2004087672.
 
"Preparation of Migrastatin Analogs and their Biological Activity" Danishefsky, S. J.; Gaul, C.; Njardarson, J. T.; PCT Int. Appl., (2004), WO 2004087673. 
 
 "Synthesis of Epothilones for Therapeutic use as Anticancer Agents" Danishefsky, S. J.; Biswas, K.; Chappell, M. D.; Lin, H.; Njardarson, J. T.; Lee, C.; Rivkin, A.; Chou, T.-C.  PCT Int. Appl. (2003), WO 2003022844.