Department of Chemistry and Chemical Biology
Department of Chemistry and
Chemical Biology
Jon C. Clardy (1943 - )
Cornell Faculty 1978 - 2003
Organic Chemistry
Chair
Education
PhD, Harvard University, 1969
Biographies
Academic Geneaology
http://www.scs.uiuc.edu/~mainzv/Web_Genealogy/index.htm
(Sept 24, 2004)
Clardy, Jon Christel (1943-) (PhD 1969, Harvard)
Gougoutas, Jack Zanas (1939-) (PhD 1964, Harvard)
Woodward, Robert Burns (1917-1979) (PhD 1937, MIT) []
Ashdown, Avery Allen (1891-1970) (PhD 1924, MIT)
Norris, James, Flack (1871-1940) (PhD 1895, Johns Hopkins)
Ira Remsen (1846-1927) (PhD 1870, Göttingen)
Heinrich Franz Peter Limpricht (1827-1909) (PhD 1850, Göttingen)
Friedrich Wöhler (1800-1882) (MD 1823, Heidelberg)
Leopold Gmelin (1753-1853) (PhD 1812, Göttingen)
Friedrich Stromeyer (1776-1835) (MD 1800, Göttingen)
Louis Nicolas Vauquelin (1763-1829) (MA 1790, Paris)
Antoine Francois de Fourcroy (1755-1809) (MD 1780, Paris)
Jean Baptiste Michel Bucquet (1746-1780) (MD 1770, Paris)
Antoine Laurent Lavoisier (1743-1794) (LLB 1758, Paris)
Guillaume Francois Rouelle (1703-1770) (Apothecary 1725, Paris)
Selected Publications
Clardy, Jon C.; Choi, Jungwon. Crystal structure of ternary complex of FRB domain of human FRAP protein, rapamycin, and human FK506-binding protein and molecular modeling of three-dimensional structure for rational drug design. U.S. (2003), 64 pp.
Calero, Guillermo; Gupta, Praveena; Nonato, M. Cristina; Tandel, Sagun; Biehl, Edward R.; Hofmann, Sandra L.; Clardy, Jon. The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2. Journal of Biological Chemistry (2003), 278(39), 37957-37964.
Jin, Mi; Wright, Sandra A. I.; Beer, Steven V.; Clardy, Jon. The biosynthetic gene cluster of pantocin A provides insights into biosynthesis and a tool for screening. Angewandte Chemie, International Edition (2003), 42(25), 2902-2905.
Jin, Mi; Liu, Liang; Wright, Sandra A. I.; Beer, Steven V.; Clardy, Jon. Structural and functional analysis of pantocin A: An antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes. Angewandte Chemie, International Edition (2003), 42(25), 2898-2901.
Sinars, Cindy R.; Cheung-Flynn, Joyce; Rimerman, Ronald A.; Scammell, Jonathan G.; Smith, David F.; Clardy, Jon. Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proceedings of the National Academy of Sciences of the United States of America (2003), 100(3), 868-873.
Brady, Sean F.; Clardy, Jon. Synthesis of Long-Chain Fatty Acid Enol Esters Isolated from an Environmental DNA Clone. Organic Letters (2003), 5(2), 121-124.
Calero, Guillermo; Wilson, Kristin F.; Ly, Thi; Rios-Steiner,
Jorge L.;
Clardy, Jon C.; Cerione, Richard A. Structural basis of m7GpppG
binding to
the nuclear cap-binding protein complex. Nature Structural Biology
(2002), 9(12), 912-917. CODEN: NSBIEW ISSN:1072-8368. CAN 138:217022
AN 2002:888177 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Brady, Sean F.; Chao, Carol J.; Clardy, Jon. New Natural Product
Families
from an Environmental DNA (eDNA) Gene Cluster. Journal of the
American
Chemical Society (2002), 124(34), 9968-9969. CODEN: JACSAT
ISSN:0002-7863. CAN 137:120474 AN 2002:576031 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Nonato, M. Cristina; Widom, Joanne; Clardy, Jon. Crystal structure
of the
N-terminal segment of human eukaryotic translation initiation
factor 2a
Journal of Biological Chemistry (2002), 277(19), 17057-17061.
CODEN:
JBCHA3 ISSN:0021-9258. CAN 137:89872 AN 2002:371295 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Liu, Shenping; Cerione, Richard A.; Clardy, Jon. Structural
basis for the
guanine nucleotide-binding activity of tissue transglutaminase
and its
regulation of transamidation activity. Proceedings of the National
Academy of Sciences of the United States of America (2002), 99(5),
2743-2747. CODEN: PNASA6 ISSN:0027-8424. CAN 136:337016 AN 2002:224848
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Wagenaar, Melissa M.; Gibson, Donna M.; Clardy, Jon. Akanthomycin,
a new
antibiotic pyridone from the entomopathogenic fungus Akanthomyces
gracilis.
Organic Letters (2002), 4(5), 671-673. CODEN: ORLEF7
ISSN:1523-7060. CAN 136:306488 AN 2002:96243 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Sutton, Amanda E.; Clardy, Jon. Synthesis and Biological Evaluation
of
Analogues of the Antibiotic Pantocin B. Journal of the American
Chemical
Society (2001), 123(41), 9935-9946. CODEN: JACSAT ISSN:0002-7863.
CAN
136:37427 AN 2001:686057 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Brady, Sean F.; Bondi, Shana M.; Clardy, Jon. The guanacastepenes:
A highly
diverse family of secondary metabolites produced by an endophytic
fungus.
Journal of the American Chemical Society (2001), 123(40), 9900-9901.
CODEN: JACSAT ISSN:0002-7863. CAN 136:17753 AN 2001:667373 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Wagenaar, Melissa M.; Clardy, Jon. Two new roridins isolated
from
Myrothecium sp. Journal of Antibiotics (2001), 54(6), 517-520.
CODEN: JANTAJ ISSN:0021-8820. CAN 135:254222 AN 2001:501741 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Wagenaar, Melissa M.; Clardy, Jon. Dicerandrols, New Antibiotic
and
Cytotoxic Dimers Produced by the Fungus Phomopsis longicolla Isolated
from
an Endangered Mint. Journal of Natural Products (2001), 64(8),
1006-1009. CODEN: JNPRDF ISSN:0163-3864. CAN 136:2565 AN 2001:484259
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Brady, Sean F.; Chao, Carol J.; Handelsman, Jo; Clardy, Jon.
Cloning and
Heterologous Expression of a Natural Product Biosynthetic Gene
Cluster from
eDNA. Organic Letters (2001), 3(13), 1981-1984. CODEN: ORLEF7
ISSN:1523-7060. CAN 135:328001 AN 2001:381244 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Clardy, Jon. Chemistry of natural products. Abstracts of Papers,
221st
ACS National Meeting, San Diego, CA, United States, April 1-5,
2001
(2001), ORGN-459. CODEN: 69FZD4 AN 2001:202961 CAPLUS (Copyright
2004 ACS on SciFinder (R))
Clardy, Jon; Jin, Mi; Sutton, Amanda; Brady, Sean; Lee, Julie.
Natural
products and the heterologous expression of biosynthetic pathways.
Abstracts of Papers, 221st ACS National Meeting, San Diego, CA,
United
States, April 1-5, 2001 (2001), MEDI-005. CODEN: 69FZD4 AN
2001:201900 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Sutton, A. E.; Clardy, J.. The synthesis of potentially selective
inhibitors
of dihydroorotate dehydrogenase. The utilization of chemoselective
Suzuki
cross-coupling reactions in a parallel synthesis. Tetrahedron
Letters
(2001), 42(4), 547-551. CODEN: TELEAY ISSN:0040-4039. CAN 134:295596
AN 2001:85102 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Brady, Sean F.; Clardy, Jon. Long-Chain N-Acyl Amino Acid Antibiotics
Isolated from Heterologously Expressed Environmental DNA. Journal
of the
American Chemical Society (2000), 122(51), 12903-12904. CODEN:
JACSAT
ISSN:0002-7863. CAN 134:158346 AN 2000:904636 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Brady, Sean F.; Singh, Maya P.; Janso, Jeff E.; Clardy, Jon.
Cytoskyrins A
and B, new BIA active bisanthraquinones isolated from an endophytic
fungus.
Organic Letters (2000), 2(25), 4047-4049. CODEN: ORLEF7
ISSN:1523-7060. CAN 134:112767 AN 2000:818609 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Brady, Sean F.; Wagenaar, Melissa M.; Singh, Maya P.; Janso,
Jeff E.; Clardy,
Jon. The cytosporones, new octaketide antibiotics isolated from
an
endophytic fungus. Organic Letters (2000), 2(25), 4043-4046. CODEN:
ORLEF7 ISSN:1523-7060. CAN 134:128287 AN 2000:818608 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Wagenaar, Melissa M.; Corwin, Jennifer; Strobel, Gary; Clardy,
Jon. Three
new cytochalasins produced by an endophytic fungus in the genus
Rhinocladiella. Journal of Natural Products (2000), 63(12),
1692-1695. CODEN: JNPRDF ISSN:0163-3864. CAN 134:39243 AN 2000:758677
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Brady, Sean F.; Clardy, Jon. CR377, a new pentaketide antifungal
agent
isolated from an endophytic fungus. Journal of Natural Products
(2000),
63(10), 1447-1448. CODEN: JNPRDF ISSN:0163-3864. CAN 133:307376
AN
2000:605978 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Bellizzi, John J., III; Widom, Joanne; Kemp, Christopher; Lu,
Jui-Yun; Das,
Amit K.; Hofmann, Sandra L.; Clardy, Jon. The crystal structure
of
palmitoyl protein thioesterase 1 and the molecular basis of infantile
neuronal ceroid lipofuscinosis. Proceedings of the National Academy
of
Sciences of the United States of America (2000), 97(9), 4573-4578.
CODEN: PNASA6 ISSN:0027-8424. CAN 133:57069 AN 2000:296042 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Sandler, Benjamin H.; Nikonova, Larisa; Leal, Walter S.; Clardy,
Jon. Sexual
attraction in the silkworm moth: structure of the
pheromone-binding-protein-bombykol complex. Chemistry & Biology
(2000),
7(2), 143-151. CODEN: CBOLE2 ISSN:1074-5521. CAN 132:261844 AN
2000:128482 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Brady, Sean F.; Singh, Maya P.; Janso, Jeff E.; Clardy, Jon.
Guanacastepene,
a Fungal-Derived Diterpene Antibiotic with a New Carbon Skeleton.
Journal of the American Chemical Society (2000), 122(9), 2116-2117.
CODEN: JACSAT ISSN:0002-7863. CAN 132:262452 AN 2000:118796 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Liu, Shenping; Neidhardt, Edie A.; Grossman, Trudy H.; Ocain,
Tim; Clardy,
Jon. Structures of human dihydroorotate dehydrogenase in complex
with
antiproliferative agents. Structure (London) (2000), 8(1), 25-33.
CODEN: STRUE6 ISSN:0969-2126. CAN 132:204810 AN 2000:82668 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Sutton, Amanda E.; Clardy, Jon. The Total Synthesis of Pantocin
B.
Organic Letters (2000), 2(3), 319-321. CODEN: ORLEF7 ISSN:1523-7060.
CAN 132:207684 AN 2000:20678 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Bellizzi, John J, III; Widom, Joanne; Kemp, Christopher W.;
Clardy, Jon.
Producing selenomethionine-labeled proteins with a baculovirus
expression
vector system. Structure (London) (1999), 7(11), R263-R267. CODEN:
STRUE6 ISSN:0969-2126. CAN 132:90409 AN 1999:777143 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Brady, Sean F.; Wright, Sandra A.; Lee, Julie C.; Sutton, Amanda
E.; Zumoff,
Cathy H.; Wodzinski, Richard S.; Beer, Steven V.; Clardy, Jon.
Pantocin B,
an Antibiotic from Erwinia herbicola Discovered by Heterologous
Expression
of Cloned Genes. Journal of the American Chemical Society (1999),
121(50), 11912-11913. CODEN: JACSAT ISSN:0002-7863. CAN 132:121502
AN
1999:771157 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Clardy, Jon. Introduction to Protein Structure (2nd edition)
by Carl Branden
and John Tooze. Chemistry & Biology (1999), 6(9), R257-R258.
CODEN:
CBOLE2 ISSN:1074-5521. AN 1999:612964 CAPLUS (Copyright 2004 ACS
on
SciFinder (R))
Clardy, Jon C.; Choi, Jungwon. Molecular structure of crystalline
FRAP
protein complex. U.S. (1999), 55 pp., Division of U.S. Ser. No.
735,848. CODEN: USXXAM US 5939528 A 19990817 CAN 131:175040 AN
1999:518307 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Liang, Jun; Jaffrey, Samie R.; Guo, Wei; Snyder, Solomon H.;
Clardy, Jon.
Structure of the PIN/LC8 dimer with a bound peptide. Nature Structural
Biology (1999), 6(8), 735-740. CODEN: NSBIEW ISSN:1072-8368. CAN
131:268824 AN 1999:500180 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Wang, Yong; Mueller, Ulrich G.; Clardy, Jon. Antifungal diketopiperazines
from symbiotic fungus of fungus-growing ant Cyphomyrmex minutus.
Journal
of Chemical Ecology (1999), 25(4), 935-941. CODEN: JCECD8
ISSN:0098-0331. CAN 131:85235 AN 1999:307175 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Odagaki, Y.; Hayashi, A.; Okada, K.; Hirotsu, K.; Kabashima,
T.; Ito, K.;
Yoshimoto, T.; Tsuru, D.; Sato, M.; Clardy, J.. The crystal structure
of
pyroglutamyl peptidase I from Bacillus amyloliquefaciens reveals
a new
structure for a cysteine protease. Structure (London) (1999),
7(4),
399-411. CODEN: STRUE6 ISSN:0969-2126. CAN 131:70384 AN 1999:274974
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Liang, Jun; Choi, Jungwon; Clardy, Jon. Refined structure of
the
FKBP12-rapamycin-FRB ternary complex at 2.2 .ANG. resolution.
Acta
Crystallographica, Section D: Biological Crystallography (1999),
D55(4),
736-744. CODEN: ABCRE6 ISSN:0907-4449. CAN 131:73463 AN 1999:269478
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Clardy, Jon. Borrowing to make ends meet. Proceedings of the
National
Academy of Sciences of the United States of America (1999), 96(5),
1826-1827. CODEN: PNASA6 ISSN:0027-8424. CAN 130:346678 AN 1999:180872
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Kongsaeree, Palangpon; Liang, Jun; Jensen, Roy A.; Clardy,
Jon.
Crystallization and preliminary x-ray crystallographic analysis
of the
Pseudomonas aeruginosa cyclohexadienyl dehydratase. Acta
Crystallographica, Section D: Biological Crystallography (1999),
D55(2),
539-541. CODEN: ABCRE6 ISSN:0907-4449. CAN 130:278556 AN 1999:115441
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Nassar, Nicolas; Hoffman, Gregory R.; Manor, Danny; Clardy,
Jon C.; Cerione,
Richard A. Structures of Cdc42 bound to the active and catalytically
compromised forms of Cdc42GAP. Nature Structural Biology (1998),
5(12), 1047-1052. CODEN: NSBIEW ISSN:1072-8368. CAN 130:135840
AN
1998:797693 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Liu, Shenping; Widom, Joanne; Kemp, Christopher W.; Crews,
Craig M.; Clardy,
Jon. Structure of human methionine aminopeptidase-2 complexed
with
fumagillin. Science (Washington, D. C.) (1998), 282(5392), 1324-1327.
CODEN: SCIEAS ISSN:0036-8075. CAN 130:77930 AN 1998:753488 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Zhang, Sheng; Pohner, Georg; Kongsaeree, Palangpon; Wilson,
David B.; Clardy,
Jon; Ganem, Bruce. Chorismate mutase-prephenate dehydratase from
Escherichia coli. Study of catalytic and regulatory domains using
genetically engineered proteins. Journal of Biological Chemistry
(1998), 273(11), 6248-6253. CODEN: JBCHA3 ISSN:0021-9258. CAN
129:2119
AN 1998:212628 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Liang, Jun; Clardy, Jon. Three-dimensional structure of FKBPs.
Guidebook
to Molecular Chaperones and Protein-Folding Catalysts (1997),
397-399.
CODEN: 65RBAT CAN 128:254125 AN 1998:110468 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Sandler, Benjamin; Murakami, Masahiro; Clardy, Jon. Atomic
Structure of the
Trypsin-Aeruginosin 98-B Complex. Journal of the American Chemical
Society (1998), 120(3), 595-596. CODEN: JACSAT ISSN:0002-7863.
CAN
128:164329 AN 1998:69143 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Schultz, L. Wayne; Clardy, Jon. Chemical inducers of dimerization:
the
atomic structure of FKBP12-FK1012A-FKBP12. Bioorganic & Medicinal
Chemistry Letters (1998), 8(1), 1-6. CODEN: BMCLE8 ISSN:0960-894X.
CAN 128:202112 AN 1998:48466 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Odagaki, Yoshi; Clardy, Jon. Structural Basis for Peptidomimicry
by the
Effector Element of Rapamycin. Journal of the American Chemical
Society
(1997), 119(42), 10253-10254. CODEN: JACSAT ISSN:0002-7863. CAN
127:289599 AN 1997:665100 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Clardy, Jon. Natural products and their macromolecular targets.
Book of
Abstracts, 214th ACS National Meeting, Las Vegas, NV, September
7-11
(1997), ORGN-138. CODEN: 64RNAO AN 1997:488540 CAPLUS (Copyright
2004 ACS on SciFinder (R))
Clardy, Jon C.; Choi, Jungwon. FKBP12-rapamycin-associated
protein FRAP
ternary complexes with FKB12 and rapamycin, crystal structure
and
conformation, and rapamycin analogs as immunosuppressants. PCT
Int.
Appl. (1997), 100 pp. CODEN: PIXXD2 WO 9715659 A1 19970501 CAN
126:325495 AN 1997:366397 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Lee, Julie C.; Coval, Stephen J.; Clardy, Jon. A cholesteryl
ester transfer
protein inhibitor from an insect-assocd. fungus. Journal of Antibiotics
(1996), 49(7), 693-696. CODEN: JANTAJ ISSN:0021-8820. CAN 125:137385
AN 1996:463931 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Zhang, Sheng; Kongsaeree, Palangpon; Clardy, Jon; Wilson, David
B.; Ganem,
Bruce. Site-directed mutagenesis of monofunctional chorismate
mutase
engineered from the E. coli P-protein. Bioorganic & Medicinal
Chemistry
(1996), 4(7), 1015-1020. CODEN: BMECEP ISSN:0968-0896. CAN 125:161984
AN 1996:463866 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Choi, Jungwon; Chen, Jie; Schreiber, Stuart L.; Clardy, Jon.
Structure of
the FKBP12-rapamycin complex interacting with the binding domain
of human
FRAP. Science (Washington, D. C.) (1996), 273(5272), 239-242.
CODEN:
SCIEAS ISSN:0036-8075. CAN 125:104589 AN 1996:424817 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Lee, Julie C.; Strobel, Gary A.; Lobkovsky, Emil; Clardy, Jon.
Torreyanic
acid: a selectively cytotoxic quinone dimer from the endophytic
fungus
Pestalotiopsis microspora. Journal of Organic Chemistry (1996),
61(10), 3232-3. CODEN: JOCEAH ISSN:0022-3263. CAN 124:311920 AN
1996:259874 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Liang, Jun; Chen, James K.; Schreiber, Stuart L.; Clardy, Jon.
Crystal
structure of PI3K SH3 domain at 2.0 .ANG. resolution. Journal
of
Molecular Biology (1996), 257(3), 632-43. CODEN: JMOBAK
ISSN:0022-2836. CAN 124:254514 AN 1996:223215 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Liang, Jun; Ealick, Steve; Nielsen, Chris; Schreiber, Stuart
L.; Clardy, Jon.
Crystallization and preliminary x-ray analysis of twinned crystals
of a
chimeric FK506 binding protein 12 and 13 complexed with FK506.
Acta
Crystallographica, Section D: Biological Crystallography (1996),
D52(1),
207-10. CODEN: ABCRE6 ISSN:0907-4449. CAN 124:110336 AN 1996:70644
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Clardy, Jon; He, Haiyin. Biologically active amides containing
a bicyclo
moiety. U.S. (1995), 6 pp. CODEN: USXXAM US 5476953 A 19951219
CAN 124:165232 AN 1996:50709 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Liang, Jun; Hung, Deborah T.; Schreiber, Stuart L.; Clardy,
Jon. Structure
of the Human 25 kDa FK506 Binding Protein Complexed with Rapamycin.
Journal of the American Chemical Society (1996), 118(5), 1231-2.
CODEN:
JACSAT ISSN:0002-7863. CAN 124:135069 AN 1996:46906 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Lee, Julie C.; Yang, Xianshu; Schwartz, Mark; Strobel, Gary;
Clardy, Jon.
The relationship between an endangered North America tree and
an endophytic
fungus. Chemistry & Biology (1995), 2(11), 721-7. CODEN: CBOLE2
ISSN:1074-5521. CAN 124:25795 AN 1995:966423 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Lee, Julie C.; Lobkovsky, Emil; Pliam, Nathan B.; Strobel,
Gary; Clardy, Jon.
Subglutinols A and B: Immunosuppressive compounds from the endophytic
fungus Fusarium subglutinans. Journal of Organic Chemistry (1995),
60(22), 7076-7. CODEN: JOCEAH ISSN:0022-3263. CAN 123:280414 AN
1995:865237 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Lee, A Y.; Stewart, J D.; Clardy, J.; Ganem, B. New insight
into the
catalytic mechanism of chorismate mutases from structural studies.
Chemistry & Biology (1995), 2(4), 195-203. CODEN: CBOLE2
ISSN:1074-5521. CAN 123:77819 AN 1995:616392 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Hughes, Philip; Clardy, Jon. Total Synthesis of
3(S)-Carboxy-4(S)-hydroxy-2,3,4,5-tetrahydropyridazine, an Unusual
Amino
Acid Constituent of Luzopeptin A. [Erratum to document cited in
CA111:39846]. Journal of Organic Chemistry (1995), 60(9), 2950.
CODEN: JOCEAH ISSN:0022-3263. CAN 123:33602 AN 1995:520672 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Schultz, L. Wayne; Clardy, Jon. 9,11-Secogorgost-5-en-9-one-3b,11-diol,
a
marine steroid from the sea whip pseudopterogorgia hummelinkii.
Acta
Crystallographica, Section C: Crystal Structure Communications
(1995),
C51(3), 415-19. CODEN: ACSCEE ISSN:0108-2701. CAN 123:33506 AN
1995:491372 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Lee, Angela Y.; Karplus, P. Angrew; Ganem, Bruce; Clardy, Jon.
Atomic
structure of the buried catalytic pocket of Escherichia coli chorismate
mutase. Journal of the American Chemical Society (1995), 117(12),
3627-8. CODEN: JACSAT ISSN:0002-7863. CAN 122:181937 AN 1995:448374
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Clardy, Jon. The chemistry of signal transduction. Proceedings
of the
National Academy of Sciences of the United States of America (1995),
92(1), 56-61. CODEN: PNASA6 ISSN:0027-8424. CAN 122:71606 AN
1995:303369 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Lee, Angela Y.; Smitka, Tim A.; Bonjouklian, Rosanne; Clardy,
Jon. Atomic
structure of the trypsin-A90720A complex: a unified approach to
structure
and function. Chemistry & Biology (1994), 1(2), 113-17. CODEN:
CBOLE2 ISSN:1074-5521. CAN 122:309664 AN 1995:198192 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
McWilliams, J. Chris; Clardy, Jon. Total Synthesis of (+)-Octalactins
A and
B: Unusual Metabolites from a Marine Microbe. Journal of the American
Chemical Society (1994), 116(18), 8378-9. CODEN: JACSAT
ISSN:0002-7863. CAN 122:132809 AN 1995:58919 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Clardy, Jon. Structural studies on FK-506, cyclosporin A and
their
immunophilin complexes. Perspectives in Drug Discovery and Design
(1994), 2(1), 127-44. CODEN: PDDDEC ISSN:0928-2866. CAN 121:291835
AN
1994:691835 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Staley, Andrew L.; Clardy, Jon. Marine invertebrates and microbes
as sources
of potential antitumor compounds. Developments in Oncology (1994),
74(ANTICANCER DRUG DISCOVERY AND DEVELOPMENT), 49-61. CODEN: DEOND5
ISSN:0167-4927. CAN 121:291809 AN 1994:691809 CAPLUS (Copyright
2004
ACS on SciFinder (R))
He, Haiyin; Silo-Suh, Laura A.; Handelsman, Jo; Clardy, Jon.
Zwittermicin A,
an antifungal and plant protection agent from Bacillus cereus.
Tetrahedron Letters (1994), 35(16), 2499-502. CODEN: TELEAY
ISSN:0040-4039. CAN 121:4653 AN 1994:404653 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Schultz, L. Wayne; Martin, Patrick K.; Liang, Jun; Schreiber,
Stuart L.;
Clardy, Jon. Atomic Structure of the Immunophilin FKBP13-FK506
Complex:
insights into the Composite Binding Surface for Calcineurin. Journal
of
the American Chemical Society (1994), 116(7), 3129-30. CODEN:
JACSAT
ISSN:0002-7863. CAN 120:235689 AN 1994:235689 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Lee, Angela Y.; Hagihara, Masahiko; Karmacharya, Rakesh; Albers,
Mark W.;
Schreiber, Stuart L.; Clardy, Jon. Atomic structure of the
trypsin-cyclotheonamide A complex: lessons for the design of serine
protease inhibitors. Journal of the American Chemical Society
(1993),
115(26), 12619-20. CODEN: JACSAT ISSN:0002-7863. CAN 120:48754
AN
1994:48754 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Clardy, Jon. Structural studies of complexed FK-506 binding
protein.
Annals of the New York Academy of Sciences (1993), 685(Immunomodulating
Drugs), 37-45. CODEN: ANYAA9 ISSN:0077-8923. CAN 119:262463 AN
1993:662463 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Boyd, Michael R.; Cardellina, John H.; Fuller, Richard W.;
Snader, Kenneth
M.; Clardy, Jon. Octene derivative antitumor compound from red
alga.
PCT Int. Appl. (1993), 28 pp. CODEN: PIXXD2 WO 9316024 A1
19930819 CAN 119:195660 AN 1993:595660 CAPLUS (Copyright 2004
ACS on
SciFinder (R))
Hallock, Yali F.; Lu, Helen S. M.; Clardy, Jon; Strobel, Gary
A.; Sugawara,
Fumio; Samsoedin, Renni; Yoshida, Shigeo. Triticones, spirocyclic
lactams
from the fungal plant pathogen Drechslera tritici-repentis. Journal
of
Natural Products (1993), 56(5), 747-54. CODEN: JNPRDF ISSN:0163-3864.
CAN 119:135119 AN 1993:535119 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Delgado, Antonio; Clardy, Jon. Total synthesis of (-)-ovatolide.
Journal
of Organic Chemistry (1993), 58(10), 2862-6. CODEN: JOCEAH
ISSN:0022-3263. CAN 119:28459 AN 1993:428459 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Mantus, Ellen K.; Clardy, Jon. The synthesis of dithyreanitrile.
Tetrahedron Letters (1993), 34(7), 1085-6. CODEN: TELEAY
ISSN:0040-4039. CAN 119:27903 AN 1993:427903 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Clardy, Jon C.; Asscher, Yael. Preparation of (3-chloro)neamphine
and
intermediates. U.S. (1992), 7 pp. CODEN: USXXAM US 5164511 A
19921117 CAN 118:212760 AN 1993:212760 CAPLUS (Copyright 2004
ACS on
SciFinder (R))
Van Duyne, Gregory D.; Standaert, Robert F.; Karplus, P. Andrew;
Schreiber,
Stuart L.; Clardy, Jon. Atomic structures of the human immunophilin
FKBP-12 complexes with FK506 and rapamycin. Journal of Molecular
Biology
(1993), 229(1), 105-24. CODEN: JMOBAK ISSN:0022-2836. CAN 118:116400
AN 1993:116400 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Gupta, Sandeep; Krasnoff, Stuart B.; Renwick, J. A. A.; Roberts,
Donald W.;
Steiner, Jorge Rios; Clardy, Jon. Viridoxins A and B: novel toxins
from
the fungus Metarhizium flavoviride. Journal of Organic Chemistry
(1993), 58(5), 1062-7. CODEN: JOCEAH ISSN:0022-3263. CAN 118:97651
AN
1993:97651 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Delgado, Antonio; Clardy, Jon. Aryl trifluoromethyl ketone
hydrates as
precursors of carboxylic acids and esters. Tetrahedron Letters
(1992),
33(20), 2789-90. CODEN: TELEAY ISSN:0040-4039. CAN 117:48047 AN
1992:448047 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Andersen, Raymond J.; Allen, Theresa M.; De Silva, E. Dilip;
Racok, Julie S.;
Clardy, Jon; Brinen, Linda S. Cytotoxic imidazothiazine derivative
from
Neamphius huxleyi. U.S. (1992), 3 pp. CODEN: USXXAM US 5106969
A 19920421 CAN 117:44847 AN 1992:444847 CAPLUS (Copyright 2004
ACS
on SciFinder (R))
Falcomer, C. M.; Meinwald, Y. C.; Choudhary, I.; Talluri, S.;
Milburn, P. J.;
Clardy, Jon; Scheraga, H. A. Chain reversals in model peptides:
studies
of cystine-containing cyclic peptides. 3. Conformational free
energies of
cyclization of tetrapeptides of sequence Ac-Cys-Pro-X-Cys-NHMe.
Journal
of the American Chemical Society (1992), 114(11), 4036-42. CODEN:
JACSAT ISSN:0002-7863. CAN 116:256005 AN 1992:256005 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Gupta, Sandeep; Krasnoff, Stuart B.; Roberts, Donald W.; Renwick,
J. A. A.;
Brinen, Linda S.; Clardy, Jon. Structure of efrapeptins from the
fungus
Tolypocladium niveum: peptide inhibitors of mitochondrial ATPase.
Journal of Organic Chemistry (1992), 57(8), 2306-13. CODEN: JOCEAH
ISSN:0022-3263. CAN 116:169754 AN 1992:169754 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Van Duyne, Gregory D.; Standaert, Robert F.; Schreiber, Stuart
L.; Clardy,
Jon. Atomic structure of the rapamycin human immunophilin FKBP-12
complex.
Journal of the American Chemical Society (1991), 113(19), 7433-4.
CODEN: JACSAT ISSN:0002-7863. CAN 115:135763 AN 1991:535763 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Stout, Thomas J.; Clardy, Jon; Pathirana, I. Charles; Fenical,
William.
Aplasmomycin C: structural studies of a marine antibiotic. Tetrahedron
(1991), 47(22), 3511-20. CODEN: TETRAB ISSN:0040-4020. CAN 115:71226
AN 1991:471226 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Van Duyne, Gregory D.; Standaert, Robert F.; Karplus, P. Andrew;
Schreiber,
Stuart L.; Clardy, Jon. Atomic structure of FKBP-FK506, an
immunophilin-immunosuppressant complex. Science (Washington, DC,
United
States) (1991), 252(5007), 839-42. CODEN: SCIEAS ISSN:0036-8075.
CAN
115:41305 AN 1991:441305 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Gupta, Sandeep; Krasnoff, Stuart B.; Roberts, Donald W.; Renwick,
J. A. A.;
Brinen, Linda S.; Clardy, Jon. Structures of the efrapeptins:
potent
inhibitors of mitochondrial ATPase from the fungus Tolypocladium
niveum.
Journal of the American Chemical Society (1991), 113(2), 707-9.
CODEN:
JACSAT ISSN:0002-7863. CAN 114:38909 AN 1991:38909 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Coval, Stephen J.; Hradil, Cynthia M.; Lu, Helen S. M.; Clardy,
Jon; Satouri,
Sami; Strobel, Gary A. Pyrenoline-A and -B, two new phytotoxins
from
Pyrenophora teres. Tetrahedron Letters (1990), 31(15), 2117-20.
CODEN: TELEAY ISSN:0040-4039. CAN 113:112081 AN 1990:512081 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Forsyth, Craig J.; Clardy, Jon. Total syntheses of (+)- and
(-)-didemnenones
A and B. Anti selectivity in the intramolecular carbomercuration
reaction.
Journal of the American Chemical Society (1990), 112(9), 3497-505.
CODEN: JACSAT ISSN:0002-7863. CAN 113:23506 AN 1990:423506 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Gupta, Sandeep; Roberts, Donald W.; Renwick, J. A. A.; Ni,
Chao Zhou; Clardy,
Jon. Molecular conformation of destruxin A. Tetrahedron Letters
(1989), 30(32), 4189-92. CODEN: TELEAY ISSN:0040-4039. CAN 112:179843
AN 1990:179843 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Hughes, Philip; Clardy, Jon. Total synthesis of
3(S)-carboxy-4(S)-hydroxy-2,3,4,5-tetrahydropyridazine, an unusual
amino
acid constituent of luzopeptin A. Journal of Organic Chemistry
(1989),
54(14), 3260-4. CODEN: JOCEAH ISSN:0022-3263. CAN 111:39846 AN
1989:439846 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Wilcox, Charles F., Jr.; Lassila, Kevin R.; VanDuyne, Greg;
Lu, Helen;
Clardy, Jon. Synthesis and properties of
cycloocta[def]biphenylene-1,4-dione. Journal of Organic Chemistry
(1989), 54(9), 2190-7. CODEN: JOCEAH ISSN:0022-3263. CAN 110:192420
AN 1989:192420 CAPLUS (Copyright 2004 ACS on SciFinder (R))
Hradil, Cynthia M.; Hallock, Yali F.; Clardy, Jon; Kenfield,
Doug S.;
Strobel, Gary. Phytotoxins from Alternaria cassiae. Phytochemistry
(1988), Volume Date 1989, 28(1), 73-5. CODEN: PYTCAS ISSN:0031-9422.
CAN 110:151002 AN 1989:151002 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Hallock, Yali F.; Clardy, Jon; Kenfield, Doug S.; Strobel,
Gary.
De-O-methyldiaporthin, a phytotoxin from Drechslera siccans.
Phytochemistry (1988), 27(10), 3123-5. CODEN: PYTCAS ISSN:0031-9422.
CAN 110:72197 AN 1989:72197 CAPLUS (Copyright 2004 ACS on SciFinder
(R))
Hughes, Philip; Clardy, Jon. Total synthesis of cyclobutane
amino acids from
Atelia herbert smithii. Journal of Organic Chemistry (1988), 53(20),
4793-6. CODEN: JOCEAH ISSN:0022-3263. CAN 109:150015 AN 1988:550015
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Forsyth, Craig J.; Clardy, Jon. Total synthesis of (+)-didemnenones
A and B.
Absolute configurations of the didemnenones. Journal of the American
Chemical Society (1988), 110(17), 5911-12. CODEN: JACSAT
ISSN:0002-7863. CAN 109:149188 AN 1988:549188 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Okamoto, Kelvin T.; Clardy, Jon. Studies on a biomimetic approach
to
aerothionin and psammaplysin-A. Tetrahedron Letters (1987), 28(42),
4969-72. CODEN: TELEAY ISSN:0040-4039. CAN 108:186426 AN 1988:186426
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Clardy, Jon; Van Duyne, Greg; Gallardo, Ana; Manta, Eduardo;
Martin, Julio
D.; Perez, Cirilo; Perez, Ricardo; Ravelo, Jose L.; Rodriguez,
Matias L.;
Schulte, Gayle K. A new diterpene with two polymorphic modifications
from
a marine alga. Tetrahedron Letters (1987), 28(52), 6699-700. CODEN:
TELEAY ISSN:0040-4039. CAN 108:183637 AN 1988:183637 CAPLUS
(Copyright 2004 ACS on SciFinder (R))
Xu, Changfu; Clardy, Jon; Carr, Richard V. C.; Kunzer, Hermann;
Nakamura,
Koichi; Paquette, Leo A. Crystallographic analysis of structural
effects
associated with symmetrical 1,3-bridging of five-membered rings
by carbonyl
spacers. Tetrahedron (1987), 43(13), 2909-14. CODEN: TETRAB
ISSN:0040-4020. CAN 108:131095 AN 1988:131095 CAPLUS (Copyright
2004
ACS on SciFinder (R))
Clardy, Jon; Van Duyne, Greg; Gonzalez, Antonio G.; Manta,
Eduardo; Martin,
Julio D.; Perez, Cirilo; Ravelo, Jose L.; Schulte, Gayle K. A
new
tricarbocyclic diterpene with a novel carbon skeleton from a marine
alga.
Journal of the Chemical Society, Chemical Communications (1987),
(10),
767-8. CODEN: JCCCAT ISSN:0022-4936. CAN 107:112629 AN 1987:512629
CAPLUS (Copyright 2004 ACS on SciFinder (R))
Talluri, S.; Montelione, G. T.; Van Duyne, G.; Piela, L.; Clardy,
J.;
Scheraga, H. A. Conformational properties of 2,4-methanoproline
(2-carboxy-2,4-methanopyrrolidine) in peptides: evidence for
2,4-methanopyrrolidine asymmetry based on solid-state x-ray
crystallography, proton NMR in aqueous solution, and CNDO/2 conformational
energy calculations. Journal of the American Chemical Society
(1987),
109(15), 4473-7. CODEN: JACSAT ISSN:0002-7863. CAN 107:59452 AN
1987:459452 CAPLUS (Copyright 2004 ACS on SciFinder (R))